DISCOVERY & DEVELOPMENT SERVICES
Our clients take advantage of our knowledge and competences to expedite their drug discovery programmes.
Services can be accessed as standalone projects or may be integrated as a part of a medicinal chemistry optimization programme to build customized solutions to meet drug discovery needs, from hit identification and follow-up, to lead optimization and back-up identification. Competencies include dealing with pharmaco-kinetics and -dynamics, solubility and permeability issues, toxicity and side effects
LDS Computational Chemistry provides a wide range of computational and research tools as well as the expertise to effectively and efficiently support drug discovery programs from hit identification, lead identification and optimization. Depending on customer’s available experimental information, ad hoc modeling approach will be chosen among a wide range of tools including ligand- or structure-based modelling (pharmacophore or docking), molecular dynamics, virtual screening, physicochemical property prediction, homology modelling, library design and filtering.
Design and synthesis of custom libraries and on-demand compounds from milligram to multi-gram scale by using cutting edge methodologies such us combinatorial chemistry, divergent synthesis, microwave assisted synthesis.
Fast and inexpensive screening of small- and medium-sized compound libraries that can be performed by using in vitro models at an early stage of the drug discovery pipeline to reduce future pitfalls. In vivo models are also available for advanced profiling.
LDS offers a wide range of services to support drug discovery and optimization programmes (both external and LDS-based), including: protein production and purification / assay development and validation / target-based and whole-cell HTS and compound profiling / optimization of biologicals and protein engineering.
LDS developed a proprietary ADC technology that comprises some sophisticated linker and conjugation technologies for any kind of highly cytotoxic agent. In this field, LDS offers: Development of conjugation techniques with custom antibodies / Development of attaching mode of custom toxins to antibodies / Development of proprietary antibodies bioconjugated with innovative mode of action