Lorenzo Botta, Chief Executive Officer
Lorenzo Botta has served as CEO from 2019 to the present.
Since 2019, Lorenzo is Senior Researcher of Organic Chemistry at the University of Tuscia of Viterbo, Department of Biology. Lorenzo obtained a degree with laude in Medicinal Chemistry at University of Siena in 2007, and a PhD in Medicinal Chemistry in 2010 at the same University. Between 2008 and 2012 he spent 3 months at the ETH of Zurich Department of Pharmacy in Prof. K.H. Altmann’s lab, 1 year at The Scripps Research Insitute of San Diego (USA) in Prof. K.C. Nicolaou’s lab and 1 year at Columbia University of New York (USA) Department of Chemistry in Prof. S.A. Snyder’s Lab. His academic accomplishments include authorship of over 45 scientific papers, and over 10 proceedings at congresses, and membership of the Scientific and/or Organizing Committees of several scientific Schools and Meetings.
Maurizio Taddei, Chief Scientific Officer and Head of Chemistry
Maurizio Taddei was one of the Members who co-founded LDS Lead Discovery Siena. He serves as Chief Scientific Officer and Head of Chemistry.
Since 2001 he is Professor of Organic Chemistry at the faculty of Pharmacy of the University of Siena, now Department of Biochemistry, Chemistry and Pharmacy. At University of Siena he served as Director of the Doctoral School in Pharmaceutical Sciences (2005-2008), as Rector Delegate for Research (2009-2012) and Director of the Department of Biochemistry, Chemistry and Pharmacy (2012-2015).
Maurizio obtained a Doctoral Degree in Chemistry in 1979 at the Department of Organic Chemistry of the University of Florence. He performed post-doctoral research at the Department of Organic Chemistry in Florence and at CNR, Institute for Heteroatom Chemistry (ICOCEA) in Bologna, (1980-1983), and University Chemical Laboratories in Cambridge (UK) with Dr. Ian Fleming (1984-1985).
In 1983 he became Research Assistant at the University of Florence and in 1992 Associate Professor at the Faculty of Agronomy of the University of Florence. In 1994 he became Professor of Organic Chemistry at the Faculty of Science at the University of Sassari.
In 1990 he got the "G. Ciamician" silver medal of the Organic Chemistry Division of the Italian Chemical Society and in 2012 the annual Research Prize for Organic Synthesis from the Organic Chemistry Division of the Italian Chemical Society.
He has been responsible of a local unity of financed PRIN projects (2000, 2003, 2006 and 2009) and responsible of several project financed by private Italian and European societies as: Dipharma -Francis (Milano), Sigma-tau Farmaceutici, (Pomezia), Prestwick Chemical (Strasburg), Chemo (Madrid). He is associate member of CNR-ICCOM (Istituto sulla Chimica dei Composti Organometallici, Florence) since 2010. He is author of more than 220 papers on scientific journals in the field of organic synthesis, bioorganic chemistry and medicinal chemistry, and 15 patents.
Jean Denis Docquier, Head of Biology
Jean Denis Docquier joined LDS as Head of Biology in 2013. Dr. Docquier obtained his Ph. D. in Biochemistry in 2002 (University of Liège, Belgium) and is Associate Professor of Microbiology at the University of Siena (Italy).
Dr. Docquier received an extensive training in both biochemistry and microbiology, and developed research projects focused on the molecular study of antibiotic mechanism of action and resistance, with a peculiar focus on β-lactamases, which he has been studying for 17 years.His main areas of research are the clinical aspects and molecular epidemiology of bacterial resistance to antibiotics; the functional and structural characterization of β-lactamases, most importantly metallo-β-lactamases and serine-carbapenemases, as effectors of β-lactam resistance in clinically-relevant Gram-negative pathogens and as targets for enzyme inhibitors; and the discovery, optimization and characterization of novel compounds with antimicrobial properties.
Dr. Docquier is the author of 66 original articles published in international peer-reviewed journals (ISI h-index, 27), 4 reviews and two book chapters published by the American Society for Microbiology (ASM) and Nova Publishing (NY, USA).He received awards from the American Society for Microbiology and the European Society of Clinical Microbiology and Infectious Diseases.He is a member of the editorial board of Antimicrobial Agents and Chemotherapy, Biochemical Pharmacology, and the European Journal of Microbiology and Immunology. He is also a member of the evaluation panels of several public research agencies
Fabrizio Manetti, Board Member
Fabrizio Manetti was one of the Members who co-founded LDS. From 2015, he is an associate professor of Medicinal Chemistry at University of Siena.
Fabrizio received a Ph.D. in Medicinal Sciences from the University of Siena in 1996. He is author or co-author of 142 papers and reviews in international journal, 17 national and international patents and more than 60 posters and oral communications.
Serena Pasquini, Board Member
Serena Pasquini has been part of the Lead Discovery Siena staff since 2013, first as Administrative and CEO Assistant, and as a board member since April 2014.
Her tasks concern administrative processes and financial management, and management of human resource practices. Her activities mostly apply to the preparation of official documents such as agreements, reports, contracts, and payroll; management of supply processes, sales invoices and issuing refunds, credit recovery, sponsor visit organization, and dealings with accountants and suppliers. She is also responsible for invoice emission and management, Human Resources processes, stage/internship/job vouchers, internal documentation, and relationships with a Labour Consultant.
Serena graduated with honours in Chemistry and Pharmaceutical Technology in April 2004 at the University of Siena where she then obtained a PhD in Pharmaceutical Sciences in 2007. Over the course of her academic career, she spent four months at the Uppsala University (Sweden) working in the field of organic synthesis. From 2007 to 2012 she was a Research Assistant at the Department of Biotechnologies Chemistry and Pharmacy at the University of Siena. She is also co-author of 29 articles in peer-viewed journals.